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ARID5B activates the TAL1-induced core regulatory circuit and the MYC oncogene in T-ALL

[演者] Wei Zhong Leong:1
[著者] Shi Hao Tan:1, Phuong Cao Thi Ngoc:1, Stella Amanda:1, Alice Wei Yee Yam:1, Wei-Siang Liau:1, Zhiyuan Gong:2, Lee N. Lawton:1, Daniel G. Tenen:1,3,4,5, Takaomi Sanda:1,5
1:Cancer Science Institute of Singapore, National University of Singapore, Singapore, 2:Department of Biological Sciences, National University of Singapore, Singapore, 3:Harvard Medical School, Boston, Massachusetts, USA, 4:Harvard Stem Cell Institute, Boston, Massachusetts, USA, 5:Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Genetic and epigenetic landscape of pediatric T-cell acute lymphoblastic leukemia (T-ALL)

[演者] Shunsuke Kimura (木村 俊介):1,2
[著者] Masafumi Seki (関 正史):1, Tomoko Kawai (河合 智子):3, Kenichi Yoshida (吉田 健一):4, Yuichi Shiraishi (白石 友一):5, Kenichi Chiba (千葉 健一):5, Tomoya Isobe (磯部 知弥):1, Hiroo Ueno (上野 浩生):4, Hiromichi Suzuki (鈴木 啓道):4, Keisuke Kataoka (片岡 圭亮):4, Hiroko Tanaka (田中 洋子):5, Masaharu Akiyama (秋山 政晴):6, Kentaro Ohki (大木 健太郎):7, Toshihiko Imamura (今村 俊彦):8, Nobutaka Kiyokawa (清河 信敬):7, Masao Kobayashi (小林 正夫):2, Katsuyoshi Koh (康 勝好):9, Ryoji Hanada (花田 良二):9, Atsushi Manabe (真部 淳):10, Akira Ohara (小原 明):11, Masashi Sanada (真田 昌):12, Yasuhide Hayashi (林 泰秀):13, Kenichiro Hata (秦 健一郎):3, Satoru Miyano (宮野 悟):5, Seishi Ogawa (小川 誠司):4, Junko Takita (滝田 順子):1
1:Department of Pediatrics, The University of Tokyo Hosipital, Tokyo, Japan, 2:Department of Pediatrics, Hiroshima University, Hiroshima, Japan, 3:Maternal/Fetal-Biology, National Center for Child Health/Development, Tokyo, Japan, 4:Graduate School of Medicine, Kyoto University, Kyoto, Japan, 5:Human-Genome Center, Institute of Medical Science, Tokyo University, Tokyo, Japan, 6:Department of Pediatrics, The Jikei University, Tokyo, Japan, 7:Hematology/Oncology, National Center for Child Health and Development, Tokyo, Japan, 8:Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan, 9:Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan, 10:Department of Pediatrics, St. Luke's International Hospital, Tokyo, Japan, 11:Department of Pediatrics, Toho University, Tokyo, Japan, 12:National Hospital Organization Nagoya Medical Center, Nagoya, Japan, 13:Gunma Children's Medical Center, Shibukawa, Gunma, Japan

Hypoxic adaptation of leukemic cells in the CNS affords a therapeutic strategy targeting VEGFA

[演者] Itaru Kato (加藤 格):1,2,3
[著者] Yoko Nishinaka-Arai (西中 瑶子):2, Masahiro Nakamura (中村 正裕):4, Ayse Akarca:5, Akira Niwa (丹羽 明):2, Hiroki Ozawa (小澤 弘樹):3, Kenichi Yoshida (吉田 健一):6, Makiko Mori (森 麻希子):7, Dapeng Wang:2,8, Makiko Morita (森田 真紀子):9, Hiroo Ueno (上野 浩生):1,6, Yusuke Shiozawa (塩澤 裕介):10, Yuichi Shiraishi (白石 友一):11, Satoru Miyano (宮野 悟):11, Rajeev Gupta:3, Katsutsugu Umeda (梅田 雄嗣):1, Kenichiro Watanabe (渡邉 健一郎):12, Katsuyoshi Koh (康 勝好):7, Souichi Adachi (足立 壮一):9, Toshio Heike (平家 俊男):1, Megumu Saito (斎藤 潤):2, Masashi Sanada (真田 昌):13, Seishi Ogawa (小川 誠司):6, Teresa Marafioti:5, Akira Watanabe (渡辺 亮):4, Tatsutoshi Nakahata (中畑 龍俊):2, Tariq Enver:3
1:Pediatrics, Kyoto Univ., Kyoto, Japan, 2:Department of Clinical Application, CiRA, Kyoto University, Kyoto, Japan, 3:Cancer Institute, University College London, London, United Kingdom, 4:Sequencing Core Facility, CiRA, Kyoto University, Kyoto, Japan, 5:Department of Cellular Pathology, University College London, London, United Kingdom, 6:Graduate School of Medicine, Kyoto University, Kyoto, Japan, 7:Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan, 8:Department of Plant Sciences, University of Oxford, Oxford, United Kingdom, 9:Human Health Sciences, Kyoto University, Kyoto, Japan, 10:Department of Pediatrics, The University of Tokyo, Tokyo, Japan, 11:Institute of Medical Science, The University of Tokyo, Tokyo, Japan, 12:Department of Hematology and Oncology, Shizuoka Children's Hospital, Shizuoka, Japan, 13:Clinical Research Center, Nagoya Medical Center, Aichi, Japan

Loss of Rheb suppresses T-ALL development without severe defects in normal hematopoiesis

[演者] Masaya Ueno (上野 将也):1
[著者] Hui Peng (彭 卉):1, Atsuo Kasada (笠田 篤郎):1, Takayuki Hoshii (星居 孝之):1, Atsushi Hirao (平尾 敦):1
1:Cancer Research Institute, Kanazawa University

Recurrent MEF2D fusions in pediatric B-precursor acute lymphoblastic leukemia and lymphoma

[演者] Kentaro Ohki (大木 健太郎):1,2
[著者] Yuya Saito (斎藤 雄弥):2, Shinsuke Hirabayashi (平林 真介):2, Motohiro Kato (加藤 元博):1,2, Kazuhiko Nakabayashi (中林 一彦):1, Myoung-Ja Park (朴 明子):2,3, Manabu Sotomatsu (外松 学):2,3, Kenichiro Hata (秦 健一郎):1, Hiroyuki Takahashi (高橋 浩之):2, Takashi Fukushima (福島 敬):2, Katsuyoshi Koh (康 勝好):2, Atsushi Manabe (真部 淳):2, Akira Ohara (小原 明):2, Yasuhide Hayashi (林 泰秀):4, Nobutaka Kiyokawa (清河 信敬):1,2
1:Natl. Cent. for Child Health and Dev., Tokyo, Japan, 2:Tokyo Childrens Cancer Study Group, Japan, 3:Dept. of Hematol. & Oncol., Gunma Childrens Medical Center, Gunma, Japan, 4:Japanese Red Cross Gunma Blood Center, Maebashi, Japan

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