Rapid Communication

Disrupted large-scale network in adolescents with Conduct Disorder

[Speaker] Yao, Shuqiao:1
[Co-author] Jiang, Yali:1
1:Medical Psychological Institute, the Second Xiangya Hospital of Central South University (China (People's Republic of China))

Background Brain imaging studies on adolescents with conduct disorder (CD) have revealed both regional deficits and abnormal connectivity compared with controls. Thus, the etiology of CD is now being increasingly treated from a systematic perspective and the analysis of brain topographical organization become more critical.
Method We computed the network organization for the first time in adolescents with non-comorbid CD and the controls (116 in total). Graph theory were employed to elucidate the structural connectivity derived from cortical thickness correlations.
Result Compared with controls, CD exhibited significant disruptions in network modularity, and their hub regions are also altered compared with controls. Moreover, the brain network of the patients is more vulnerable to either targeted attack or random failures.
Conclusion These results bring new insights into a better understanding of etiology of CD, and such misconfiguration may play a potential role in the impairment of typical development of CD's brain.
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