Mood-related impulsivity is related to abnormal prefrontal activity during emotional regulation in gambling disorder patients

[Speaker] Navas, Juan F:1
[Co-author] Contreras- Rodríguez, Oren:2, Verdejo- Román, Juan:1, Martín- Pérez, Cristina:1, Vilar- López, Raquel:1, Verdejo- García, Antonio:3, Perales, José C:1
1:University of Granada (Spain), 2:Department of Psychiatry, Bellvitge Hospital (IDIBELL) Barcelona (Spain), 3:Monash University (Australia)

Introduction and aims.
Negative urgency (NU) is associated to poor prognosis in treatment-seeking gambling disorder patients (GDPs). We aimed to investigate the neural underpinnings of NU and its potential relationship with affective dysregulation in GDPs.
Seventeen GDPs and 21 healthy controls (HCs) underwent a negative emotional regulation task (reappraising vs experiencing the emotional impact of negative pictures) during fMRI, and were assessed in NU (UPPS-P).
GDPs showed more activation than HCS in the dorsolateral prefrontal cortex (dlPFC) during the reappraising (vs experiencing) condition. In GDPs only, the activation of the dlPFC was positively related to the emotion regulation success and NU. Hyperconnectivity between the dlPFC and the inferior frontal gyrus also correlated with NU in GDPs.
The linkage between over-recruitment of top-down executive frontal structures, negative emotional regulation capacities and NU supports the importance that abnormal affective regulation processes have in gambling disorder treatment.
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