Integration of multimodal information in hippocampal-retrosplenial-prefrontal circuit

[Speaker] Terada, Satoshi:1,2
[Co-author] Sakurai, Yoshio:1, Nakahara, Hiroyuki:2, Fujisawa, Shigeyoshi:2
1:Kyoto Univ (Japan), 2:RIKEN BSI (Japan)

Decision making is often guided by multimodal stimuli. However, little is known about the neural representation for the integration of them. To approach this question, we have newly developed a behavioral task for rats, cue-combination task. Central for this task is that the correct choice of action should be determined by a combination of two cues (sound and odor). Large-scale extracellular single unit recordings in the prefrontal cortex (PFC), hippocampus (HPP), and retrosplenial cortex (RSC) during this task revealed that several neurons, referred to here as combination cells, discharge at the time of presentation of only one of the combination patterns of the sound and odor cues. Moreover, we found theta-band HPP-RSC synchrony was stronger during simultaneously presentation of odor and sound, and PFC gamma oscillation was coupled with this coherent theta oscillation. We hypothesize that their interaction might form and represent integarated information to solve exacting decision problems.
Advanced Search