Pica as an index of rats' nausea induced by exercise

[Speaker] Nakajima, Sadahiko:1
1:Kwansei Gakuin University (Japan)

It is well reported that various nausea-inducing treatments yield aberrant pica behavior (kaolin clay ingestion) in laboratory rats. The treatments include irradiation, motion sickness, and administration of emetic drugs such as lithium chloride, cyclophosphamide, and cisplatin. We have recently found that voluntary running in an activity wheel also causes pica behavior in rats (Nakajima & Katayama, 2014). A new set of experiments conducted in my laboratory revealed that forced running in a motorized wheel at a constant speed also works as an effective agent to generate pica in rats. Interestingly, voluntary running yielded more pica than forced running, even if the average number of wheel turns was greater in the former case. Furthermore, the latest experiment in my research project has shown that forced swimming in a water bucket also yields pica behavior in rats. The nature of nausea induced by these exercises will be discussed.
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