Estrogenic modulation of wheel-running activity is independent of that of fear- and anxiety-related behavior in female mice.

[Speaker] Tomihara, Kazuya:1
1:Kagoshima University (Japan)

Recently, we demonstrated that chronic estrogen treatments at higher doses results in enhanced, whereas at lower doses suppressed, fear- and anxiety-related behavior in female mice. It is well known, however, that the fear- and anxiety-related behavior measured in many behavioral test paradigms are easily affected by the general activity level of the subjects, and that estrogens modulate the activity level. Therefore, we investigated the wheel-running activity in ovariectomized female mice with an sc implantation of a Silastic capsule containing either vehicle or varied doses (0.5 μg, 50 μg/0.1 ml) of estradiol. As a result, the animals of both groups treated with estradiol showed significantly higher wheel-running activity than the animals treated with oil vehicle, though there was also significant difference in the activity level between the estradiol-treated groups. This indicates that the estrogenic regulations on fear- and anxiety-related behavior cannot be accounted for by their modulation to the general activity.
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