An injection of NMDA type receptor blocker into the dorsal striatum did not impaire the acquisition of memory for duration in a peak interval procedure

[Speaker] Hata, Toshimichi:1
1:Doshisha Univ. (Japan)

According to the Striatal Beat Frequency (SBF) model (Matell & Meck, 2004) of interval timing, the information for a stimulus duration is coded by synaptic plasticities in the dorsal striatum. We have previously reported that an intra-dorsal striatum injection of a NMDA-type glutamate receptors blocker, AP-5, impaired the memory formation for a duration. We tried to replicate the finding. Following enough number of trainings in peak interval 20-s (PI 20) procedure, the required time of the task was changed from 20-s to 40-s and the training continued for three sessions ("time-shift sessions"). Before starting each time-shift session, AP-5 (3µg, 0.5µL) or aCSF was injected into the dorsal striatum. Unlike our previous study, the shift of peak time toward 40-s in the time-shift sessions was not significantly delayed by AP-5 treatment, suggesting that the memorization of duration was not impaired.
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