Long-lasting effect of chronic neonatal treatment with MK-801 on locomotor activity in rats

[Speaker] Niikura, Ryo:1
[Co-author] Sakata, Shogo:1
1:Hiroshima University (Japan)

Chronic neonatal blockade of N-methyl-D-aspartate (NMDA) receptors produces various abnormal behaviors in animals in later life. This study systematically investigated the effects of chronic neonatal treatment with MK-801, a noncompetitive NMDA receptor antagonist, on age-related changes of locomotor activity in rats using a simple open field test. Regardless of the implementation period, rats neonatally treated with MK-801 consistently showed higher locomotor activity compared with the control group when duration of the open field test was 20 minutes. Our results suggest that chronic blockade of NMDA receptor activity in the critical period of neurodevelopment induces long-lasting psychomotor excitation. Therefore, these rats could be used as a neurodevelopmental animal model of psychiatric disorders that exhibit hyperactivity as a symptom.
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