Individual ability of fear extinction predicts their resilience to drug addiction in rats

[Speaker] Ueno, Masaharu:1
[Co-author] Yamada, Kazuo:2, Ichitani, Yukio:2
1:Graduate School of Comprehensive Human Sciences, University of Tsukuba (Japan), 2:Faculty of Human Sciences, University of Tsukuba (Japan)

Some individuals recover quickly from stressful events while others do not, suggesting individual differences in stress resilience. Studies have shown that individual ability to extinct conditioned fear would predict their stress resilience in rats. In this study, we investigated whether individuals who are resilient or vulnerable under fear conditioning would consistently show resilient or vulnerable behaviors in other behavioral tests, respectively. Male Wistar-Imamichi rats were subjected to a series of behavioral paradigms, including an open field test, a conditioned place preference test (CPP), a forced swim test, and an auditory fear conditioning. The subjects were divided into the resilient and the vulnerable groups based on their freezing levels during the fear extinction, and their other behavioral phenotypes were compared. Rats in the resilient group showed faster extinction in methamphetamine-induced CPP than rats in the vulnerable group. Results suggest that resilience to stressful events is associated with that to drug addiction.
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