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OR28-70-6

Abnormal brain activations underlying social interactive behaviors in major depressive disorder

[Speaker] Zhou, Yuan:1
[Co-author] Wang, Yun:1, Chen, Qun:2
1:Institute of Psychology, Chinese Academy of Sciences (China (People's Republic of China)), 2:Beijing AnDing Hospital, Capital Medical University (China (People's Republic of China))

To explore the neural explanations of abnormal social interactive behaviors of patients with major depressive disorder (MDD), the current study recruited 27 MDD patients and 28 matched healthy controls to perform a classical Ultimatum Game as responders during functional magnetic resonance imaging scanning. Consistent with our previous study, we found that MDD patients showed decreased acceptance rate and were unable to discriminatively treat unfair offers from computer and from human proposers. More importantly, we found (1) abnormal prefrontal cortices activation while facing offers in MDD; (2) the significant correlations between the acceptance rates of [unfair-fair] offers and the brain activities in the left insula and anterior cingulate cortex and between the acceptance rates of [human-computer] offers and the brain activities in the left medial prefrontal cortex and inferior frontal gyrus in healthy controls but not in MDD. These findings provide neuroimaging explanations of abnormal social interactive behaviors in MDD.
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