Impaired working memory in patients with borderline personality disorder: An ERPs study

[Speaker] Yi, Jinyao:1
[Co-author] Liu, Ying:1, Zhong, Mingtian:2, Yao, Shuqiao:1
1:Second Xiangya Hospital of Central South University (China (People's Republic of China)), 2:School of Psychology, South China Normal University (China (People's Republic of China))

Previous studies have demonstrated that patients with borderline personality disorder(BPD) are impaired in working memory especially in high workload. But most of them just used Reaction Time(RT) and/or Accuracy Rate (AR) as standards and couldn't provide sufficient information to explore the information processing mechanisms.In this study, a modified version of N-back task (0-back and 2-back)was used to measure working memory.Event-related potentials (ERPs) were recorded in 22 BPD patients and 21 age-,handedness- and sex-matched healthy controls. Repeated measures ANOVA showed that there were no significant group differences on behavioral variables (RT and AR) or on latency and amplitude of P1 and N1 (all p>0.05), while BPD patients had lower P3 amplitudes and longer N2 latency than healthy controls, independent of working memory load, which suggests that BPD patients might not be inefficient at reallocating processing resources for working memory processing demands in high-load task compared to controls.
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