Program

SPS-05-5

Using transcranial magnetic stimulation (TMS) as a tool for primate neuroscience research

[Speaker] Tsutsui, Ken-ichiro:1
1:Tohoku University (Japan)

Non-invasive, bi-directional (excitation/inhibition) nature of transcranial magnetic stimulation (TMS) implies huge potential as an experimental tool for systems neuroscience. So far it has been used mainly for human experiments, but its application to animal experiments may give us further advantages, such as smaller safety margins for stimulus intensities and larger numbers of repeated measures to see clearer physiological and behavioral effects. Here we report our recent studies that applied repetitive TMS (rTMS) to monkeys to examine the role of the prefrontal cortex in cognitive and emotional/motivational controls. By suppressing the dorsolateral part of the prefrontal cortex (dlPFC) by low-frequency rTMS, monkeys exhibited difficulties in performing delayed response, the standard task for visuospatial working memory in monkeys. On the other hand, by suppressing the medial part of the prefrontal cortex (mPFC) by low-frequency rTMS, monkeys exhibited some symptoms that may have caused by the downregulation of mood and motivation.
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