Presentation Information

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Room
E-poster/E-video Room (Tokyo International Forum G408/G505, Imperial Hotel 2F Hana)
Topic
Ocular Imaging
 
 
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VI-84

A Novel Method to Achieve Comparability Between Spectral-Domain and Time-Domain Optical Coherence Tomography Measurement

【Author】
Colin Tan Kelvin Li Tock Han Lim


Objective/Purpose
The quantitative assessment of retinal thickness and volume varies according to the optical coherence tomography (OCT) machine used due to differences in segmentation lines. We describe a novel method of adjusting the segmentation lines of spectral-domain OCT (SD-OCT) to enable comparison with time-domain OCT (TD-OCT).

Summary of Content
In a prospective study, SD-OCT (Spectralis OCT) and TD-OCT (Stratus OCT) were sequentially performed on 200 eyes of 100 healthy individuals. Central retinal thickness (CRT), central point thickness (CPT), and 1-mm volume of the Early Treatment Diabetic Retinopathy Study grid were compared between the two machines. The segmentation lines on SD-OCT were manually adjusted by a trained operator and the parameters compared again with TD-OCT. The mean CRTs of Spectralis and Stratus were significantly different (266.6 μm vs. 192.2 μ m, P < 0.001). After adjustment of segmentation lines, the mean adjusted Spectralis CRT was 198.0 μm, with the difference between SDOCT and TD-OCT measurements decreasing from 74.4 μ m to 3.8 μ m (P < 0.001). Similar trends were obtained for central 1-mm volumes and CPT. Interoperator and intraoperator repeatability for adjustment of the segmentation lines were good, with an intraclass correlation of 0.99 for both. Manual adjustment of SD-OCT segmentation lines reliably achieves retinal thickness and volume measurements that are comparable to that of TD-OCT. This is valuable to allow comparisons in multicenter clinical trials where different OCT machines may be used.

[ Keyword ]
Optical Coherence Tomography

[ Conflict of Interest ]
No

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