Duration 5min, Q&A 3min
Corneal Endothelial Damage after Cataract Surgery in Eyes with Pseudoexfoliation Syndrome
To compare corneal endothelial cell damage and anterior chamber inflammation following cataract surgery between eyes with and without pseudoexfoliation syndrome (PEX).
Thirty-six eyes with PEX (PEX group) and 36 age-matched eyes without PEX (non-PEX group) scheduled for phacoemulsification surgery were enrolled.
Preoperatively and at 1 and 3 months postoperatively, corneal endothelial cell density (ECD) and central corneal thickness (CCT) were measured using a specular microscope, flare intensity was measured using a flare meter, and central macular thickness was measured using optical coherence tomography (OCT).
Results and Conclusion
Mean ECD was significantly lower in the PEX group than in the non-PEX group preoperatively and postoperatively (P ≦ .0250). The percentage of endothelial cell loss was significantly greater in the PEX group than in the non-PEX group (P ≦ .0216); the percentage was 9.0% in the PEX group and 3.4% in the non-PEX group at 3 months postoperatively. Mean CCT was similar between groups throughout the follow-up period, but the percent increase in CCT was significantly greater in the PEX group than in the non-PEX group at 1 month postoperatively (P = .0152). Flare intensity and foveal thickness did not differ significantly between groups throughout the follow-up period (P ≧ .3079).
Conclusions: Corneal endothelial cell loss and transient increase in CCT are greater after cataract surgery in eyes with PEX than in eyes without PEX. Thus, because the corneal endothelium in eyes with PEX is vulnerable to cataract surgery, careful surgical procedures are necessary.
[ Keyword ]
Pseudoexfoliation syndrome / corneal endothelial cells / central corneal thickness / cataract surgery
[ Conflict of Interest ]