Duration 5min, Q&A 3min
Comparison of Ultra-Widefield Fluorescein Angiography with the Heidelberg Spectralis® Noncontact Module Versus the Ultra-Widefield Optos® Optomap®
To compare the area of the retina imaged with ultra-widefield fluorescein angiography using the Optos® Optomap® and the Heidelberg Spectralis® noncontact ultra-widefield module.
Five patients (ten eyes) underwent ultra-widefield fluorescein angiography using both the Optos® panoramic P200Tx and the noncontact widefield module in the Heidelberg Spectralis.
The images were obtained as a single, non-steered shot centered on the macula. The area of imaged retina was outlined and quantified using Adobe® Photoshop® C5 software. The total area and area within each of four visualized quadrants was calculated and compared between the two imaging modalities. Three masked reviewers also evaluated each quadrant per eye (40 total quadrants) to determine which modality imaged the retinal vasculature most peripherally.
Results and Conclusion
Optos® captured a total retinal area averaging 151,362 pixels, (range 116,998 to 205,833), while the area captured using the Heidelberg was 101,786 pixels, (range 73,424 to 116,319), P = 0.0002. The average area per individual quadrant imaged by Optos® versus the Heidelberg Spectralis® superiorly was 32,373 vs 32,789 pixels (P = 0.91), inferiorly was 24,665 vs 26,117 pixels (P = 0.71), temporally was 47,948 vs 20,645 pixels (P= 0.0001), and nasally was 46,374 vs 22,234 pixels (P = 0.0001). Along not statistically significanly different in the imaged areas, the Heidelberg was able to image the superior and inferior retinal vasculature to a more distal point than was the Optos®, in 18 of 20 quadrants. The Optos® was able to image the nasal and temporal retinal vasculature to a more distal point than was the Heidelberg Spectralis® in all 20 of 20 quadrants.
The ultra-widefield fluorescein angiography obtained with the Optos® and Spectralis® are both excellent modalities that provide views of the peripheral retina beyond that of the traditional ETDRS 7 standard fields. On a single non-steered image, the Optos® covered a significantly larger total retinal area in all four quadrants compared to the Spectralis®. The Optos® captured an appreciably wider view of the retina temporally and nasally in all patients, while Spectralis® was able to image the superior and inferior retinal vasculature to a more distal point in some, but not all, patients. In the 10 eyes included in this pilot study, the Optos® Optomap® provided the most comprehensive field of view of the peripheral and central retina providing a truly ultra-widefield angiogram. The clinical significance of these findings as well as the area imaged on steered and montaged images remains to be determined.
[ Keyword ]
Optos / ultra-widefield / fluorescein / angiography / Heidelberg
[ Conflict of Interest ]
[ Conflict of Interest (Potential conflict) ]
Consultant, Sponsored Research from Optos, Sponsored Research from Heidelberg.