Duration 5min, Q&A 3min
Comparison Study of Accelerated and Conventional Corneal Collagen Crosslinking for Keratoconus: Preliminary Results Comparison Study of Accelerated and Conventional Corneal Collagen Crosslinking for Keratoconus; Preliminary Results
Collagen Crosslinking (CXL) is promising method to halt the progression of ectactic corneal diseases by strengthening the biomechanical stability between the collagenous strands of the cornea. Herein, we report the early clinical results and compare Accelerated CXL to Conventional CXL.
53 eyes of 35 keratoconus patients were randomly selected. 36 eyes had Accelerated CXL (ACXL) (20 minutes riboflavin presoak; 2 minutes 40 seconds of 45 mW/cm2 UVA light) and 17 eyes had Conventional CXL (CXL) (30 minutes presoak riboflavin, 30 minutes of 3 mW/cm2 UVA light).
The outcomes in terms of visual acuity, keratometric readings, endothelial cell density counts (ECD), morphological change observed by confocal microscopy, demarcation line observed by Optical coherence tomography (OCT) and biomechanical change observed by Ocular Response Analyzer (ORA) and Corvis ST were taken, analyzed and compared.
Results and Conclusion
There were no statistically significant changes between the groups in terms of uncorrected distance visual acuity, corrected distance visual acuity, manifest refractive sphere equivalence, keratometric readings, biomechanical parameters determined by ORA and Corvis ST or ECD. In addition, similar morphological changes and a pronounced demarcation line were apparent in both groups.
ACXL and conventional CXL are similar in terms of effectiveness and safety but ACXL reduces the treatment time significantly.
[ Keyword ]
Accelerated Corneal Collagen Crosslinking / keratoconus / Corneal confocal microscopy / optical coherrence tomography / Corneal biomechanics
[ Conflict of Interest ]