Duration 5min, Q&A 3min
Comparison of 3 Measurement Scales for Grading Ocular Chronic Graft-Versus-Host Disease Patients
To compare 3 measurement scales for grading ocular chronic graft-versus-host disease (cGVHD) i.e. dry eye arising after allogeneic hematopoietic stem cell transplantation (HSCT).
Eighty-three patients who underwent HSCT at Keio University School of Medicine, Tokyo, Japan were retrospectively reviewed.
The severity of ocular cGVHD was graded by 3 measurement scales: the National Institute of Health (NIH) eye score, Japanese dry eye criteria, and dry eye work shop (DEWS) 2007score.
Results and Conclusion
Fifty-seven patients (68.7%) were diagnosed as cGVHD, 21 were not diagnosed as cGVHD by NIH consensus criteria and the diagnosis of 5 cases was unknown. Among these 21 patients who were not diagnosed as cGVHD, 13 patients (15.7 %) had ocular cGVHD diagnosed by the NIH eye score. The percentages of HSCT patients who were diagnosed as ocular cGVHD by NIH eye score, Japanese dry eye criteria, and DEWS 2007 score were 68.7 %, 61.4 %, 63.9 % respectively. Ocular cGVHD was assessed as more severe by the Japanese dry eye criteria and the DEWS 2007 score than by the NIH eye score. Three cases (3.6% of all cases) however, were not diagnosed as ocular cGVHD by the Japanese dry eye criteria, but as mild or moderate ocular cGVHD by the NIH eye score. There were patients who were not diagnosed as cGVHD in other organs besides the eye by NIH consensus criteria and presented ocular cGVHD. There were some interesting discrepancies among the scores obtained by using the 3 measurement scales. Ocular cGVHD can, be the initial and/or the only manifestation of cGVHD. Future prospective, multi-center research is needed for further discussion.
[ Keyword ]
ocular chronic GVHD, dry eye, hematopoietic stem cell transplantation, NIH consensus criteria
[ Conflict of Interest ]