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[FP-SA-36] Dry Eye and Ocular Surface Disease
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Apr 05 (Sat)
08:30 - 10:00
Room 12 - Tokyo International Forum 5F G510
External Eye Disease, Cornea, Eye Banking
Chair)Elisabeth Messmer、Chair)Victoria Wong


Duration 5min, Q&A 3min

The Immune Response and Coagulation Values of Lacrimal Fluid in Case of Allergic Diseases of Eyes

Zulfiya Nazirova
Zulfiya Nazirova Dilfuza Turakulova Murod Mavlyanov

The aim of the research is the study cytokine status and coagulation activity of lacrimal fluid in case of allergic diseases of eyes in children.

There were 76 children examined with allergic diseases of eyes aged from 6 to 14 years old. The first group was 34 children with allergic alterations on the surface of eyes and the second group was 42 children with infectious alterations.

All patients got standard ophthalmologic examinations and analysis: hematologic values with calculation of leukocyte index of intoxication (LII), allergization index (AI); concentration of C-reactive protein; amount of IL-4, IL-6, FNO-α; coagulation activity of lacrimal fluid; amount of fibrinogen in the lacrimal fluid.


Results and Conclusion
According to the achieved results in the I-group there is a reliable rise of LII 3.2 times (p<0,05) in comparison with healthy children, while in the II-group there is registered average 2 times growth of AI (p<0,05).
The level of C-reactive protein in the II-group 30 times overcame the control values, while in the I-group is only 10 times (p<0,05). These results proved the nature of allergic diseases of eyes were associated with infection and allergy.
The level of IL-4 in the lacrimal fluid of the children of the II-group was 36% lower than those of the control group and in the I-group was 7% higher. IL-6 level in lacrimal fluid was 33% increased in the II-group and in the I-group its amount was decreasing in comparison with the control one. 15% rise of FNO-α in lacrimal fluid was detected in the II-group, while in the I-group there was 10% decrease in comparison with the control values. The aforesaid indicates activation of the immune response in the I-group and decrease of local inflammation in the children of the II-group.
Children of the II-group had decrease of sIgA about 24% (p<0,05), in the I-group this factor increased to 20% (p<0,05). The level of IgE in the lacrimal fluid of the children
 of the I-group increased average 2.2 times (p<0,05), that indicates intensification of chemotaxis state of eosinophiles in the lacrimal fluid. Though in the II-group that value exceeded the original level only to 43% (p<0,05).
The dynamics of the coagulation activity of lacrimal fluid and the amount of fibrinogen in case of that pathology indicates hem circulatory disorders in the vessels of retina and choriodea, proving the importance of the study of the values of hem stasis for inflammatory and allergic processes.

[ Keyword ]
allergic disease of eyes

[ Conflict of Interest ]

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