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Poster Sessions

統合失調症I
Schizophrenia I

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開催日
2010年09月02日(木)
時 間
11:00 - 12:00
会 場
Poster Room 2

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DISC1ノックアウトマウスの表現型解析
Phenotypic analysis of DISC1 knockout mice

演題番号 : P1-p03

黒田 啓介 / Keisuke Kuroda:1,7 森 大輔 / Daisuke Mori:1,7 田谷 真一郎 / Shinichiro Taya:5,7 坪井 大輔 / Daisuke Tsuboi:1,7 難波 隆志 / Takashi Namba:1,7 桑田 亮 / Ryo Kuwata:1,7 矢野 寿 / Hisashi Yano:1,7 久保田 晋平 / Shinpei Kubota:1,7 木下 貴文 / Takafumi Kinoshita:1,7 衣斐 大輔 / Daisuke Ibi:2,7 永井 拓 / Taku Nagai:2,7 山田 清文 / Kiyofumi Yamada:2,7 田中 基樹 / Motoki Tanaka:3 曽我部 正博 / Masahiro Sokabe:3 礒谷 真弓 / Mayu Isotani:4 榎本 篤 / Atsushi Enomoto:4 高橋 雅英 / Masahide Takahashi:4 清成 寛 / Hiroshi Kiyonari:6 阿部 高也 / Takaya Abe:6 貝淵 弘三 / Kozo Kaibuchi:1,7 

1:名古屋大院・医・神経情報薬理 / Dept of Cell Pharmacol, Nagoya Univ Grad Sch of Med, Nagoya, Japan 2:名古屋大院・医・医療薬学 / Dept of Neuropsychopharmacol and Hospital Phar, Nagoya Univ Grad Sch of Med, Nagoya, Japan 3:名古屋大院・医・細胞生物物理 / Dept of Physiol, Nagoya Univ Grad Sch of Med, Nagoya, Japan 4:名古屋大院・医・分子腫瘍 / Dept of Cell Pathol, Nagoya Univ Grad Sch of Med, Nagoya, Japan 5:国立精神神経センター・神経研・病態生化学 / Dept of Biochem and Cellular Biol, Natl Inst of Neurosci, NCNP, Kodaira, Japan 6:理研・発生・再生科学総合研究センター・動物資源開発室 / Lab for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biol, Kobe, Japan 7:独立行政法人科学技術振興機構, CREST / JST, CREST 

 

Schizophrenia is a severe psychiatric disorder with lifelong disability. Although the causes of schizophrenia remain largely unknown, it has been widely accepted that schizophrenia has high inheritance, indicating the existence of genetic risk factors. Disrupted-In-Schizophrenia 1 (DISC1) is a promising candidate gene for susceptibility to psychiatric disorders including schizophrenia (Brandon et al., 2009, for a review). The DISC1 gene locus was originally identified at the breakpoint of a balanced (1;11) (q42; q14) chromosome translocation that co-segregates with schizophrenia, bipolar disorder, and recurrent major depression in a large Scottish family. Further analysis indicates that inheritance of the translocation is causal and increases the risk of these psychiatric disorders. We have previously found that DISC1 links Kinesin-1 to the NUDEL/LIS1/14-3-3 epsilon complex or Grb2, and regulates their transport to axon as a cargo receptor and axon elongation (Taya et al., 2007, Shinoda et al., 2007). However, the in vivo functions of DISC1 remain elusive. Here, we generated Disc1 knockout mice. Mice homozygous for the Disc1 mutation were born from heterozygote intercrosses at approximately the frequency predicted by Mendel's law. The Disc1-/- mice were viable and fertile. No gross abnormalities, such as disorganization of the cytoarchitecture of brain were found in the mutant mice. We will discuss phenotypic analysis of DISC1 knockout mice in our presentation.

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