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Poster Sessions

学習と記憶I
Learning and Memory I

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開催日
2010年09月02日(木)
時 間
13:00 - 14:00
会 場
Poster Room 2

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記憶形成時と想起時で扁桃体外側核の類似した神経細胞集団が活性化される
Similar neuronal populations in the lateral amygdala activated during memory formation and retrieval

演題番号 : P1-m14

野中 綾子 / Ayako Nonaka:1 山本 はるか / Haruka Yamamoto:1 松木 則夫 / Norio Matsuki:1 野村 洋 / Hiroshi Nomura:1 

1:東京大院・薬・薬品作用学 / Lab of Chemical Pharmacology, Grad Sch of Pharmaceutical Sciences, The Univ of Tokyo, Tokyo 

 

Although memory is presumably stored in the subset of neurons during memory formation and read out from the same subset during memory retrieval, there is no clear evidence to confirm the idea. To establish this hypothesis, we identified neuronal populations engaged in memory formation and retrieval detecting Arc RNA, which is a neural activity marker. Mice were conditioned with footshock in a conditioning chamber. They were returned to homecage and 25 min later re-exposed to the conditioning chamber for 5 min to recall the memory. Immediately after the retrieval, we removed the brains and detected Arc RNA in the lateral amygdala by fluorescence in situ hybridization. The method enables us to distinguish neurons activated in each process. The activity of individual neurons during conditioning and re-exposure were determined by subcellular localization of Arc RNA. A number of neurons activated during conditioning were also activated during re-exposure. This result suggests that a read-out of neuronal ensemble organized during memory formation may lead to memory retrieval.

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