演題番号 : P1-b19
関山 タマミ / Tamami Sekiyama:1 中谷 康司 / Yasushi Nakatani:1 麓 正樹 / Masaki Fumoto:1 菊地 宏美 / Hiromi Kikuchi:1 于 新軍 / Xinjun Yu:1 有田 秀穂 / Hideho Arita:1
1:東邦大学 医学部 統合生理学 / Department of Physiology, Toho University. School of Medicine
We have measured serotonin levels in the whole blood (WB 5-HT) under various experimental situations. In this study, we made meta-analysis of WB 5HT in 172 healthy subjects (74 males and 98 females, age 18-84 years old) during a resting state. As a result, mean WB 5-HT levels of healthy subjects was 165.2±4.1ng/ml (Mean±S.E.); there was no significant difference in mean level of WB 5-HT level between male (160.1±6.5ng/ml) and female (168.7±5.2ng/ml). We found a negative correlation of WB 5-HT levels with age (r=-0.34, p<0.0001). Mean levels of WB 5-HT showed age-dependent decrease, as follows; 215.3±28.1ng/ml in 18-19 y.o. (n=5), 183.4±6.8ng/ml in 20-29 y.o. (n=58), 161.9±7.9ng/ml in 30-39 y.o. (n=44), 152.8±8.3ng/ml in 40-49 y.o. (n=31), 154.2±9.8ng/ml in 50-59 y.o. (n=25) and 108.5±10.2ng/ml over 60 y.o. (n=9). On the other hand, we had an opportunity to measure WB 5-HT levels in depressive subjects (3 males and 4 females, age 29-46 years) with a treatment of selective serotonin reuptake inhibitors (SSRIs; Paxil, Luvox or Depromel). These subjects showed an extremely lower WB 5-HT level (14.1±3.8ng/ml), as compared to healthy subjects. This may be explained by the mechanism that SSRIs could inhibit 5-HT transporters located at blood-brain barrier as well as pre-synaptic terminals of 5-HT neurons.