β1- and β2-Adrenergic Activations Enhance Excitatory Synaptic Transmission in Layer V/VI Pyramidal Neurons of the Medial Prefrontal Cortex of Rats
演題番号 : P1-b09
1:Institute of Neurobiology, Fudan University,Shanghai,China
β-Adrenoceptors (β-ARs) are widely distributed throughout the central nervous system. Our previous work showed that β-AR activation facilitates excitatory synaptic transmission in pyramidal cells of the medial prefrontal cortex (mPFC). However, little is known about the β1- and β2-AR regulations of synaptic transmission in the mPFC. The present study investigated β1- and β2-AR modulation of glutamate synaptic transmission in layer V/VI pyramidal cells of the rat mPFC. Our results show that, 1) stimulation of β1-ARs does not affect the frequency nor the amplitude of mEPSCs, and stimulation of β2-ARs increases the frequency but not amplitude of mEPSCs; 2) stimulation of β2-ARs suppresses the paired-pulse ratio of eEPSC, and stimulation of β1-ARs does not; and 3) stimulations of β1- and β2-ARs both enhance the amplitude of eEPSC and non-MDA-R current and NMDA-induced currents. Taken together, these results suggest that β1- and β2-AR activations both facilitate excitatory synaptic transmission in mPFC pyramidal cells.