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神経伝達物質・修飾物質
Neurotransmitters and Modulators

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開催日
2010年09月02日(木)
時 間
11:00 - 12:00
会 場
Poster Room 1

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VGAT-Venus トランスジェニックマウスを用いた扁桃体外側核のカルシウム結合タンパク質陽性GABA作動性ニューロンの免疫組織化学的解析
Immunohistochemical characterization of calcium-binding protein-containing GABAergic neurons in the lateral amygdala using vesicular GABA transporter (VGAT)-Venus transgenic mice

演題番号 : P1-b03

張 月 / Yue Zhang:1,2 三輪 秀樹 / Hideki Miwa:1,2 柳川 右千夫 / Yuchio Yanagawa:1,2 

1:群馬大学大学院 医学系研究科遺伝発達行動学 / Department of Genetic and behavioral Neuroscience, Gunma University School of Medicine, Maebashi, Japan 2:独立行政法人科学技術振興機構、CREST / JST, CREST,Tokyo, Japan 

 

The amygdala performs a primary role in emotional behavior and learning. The lateral nucleus of the amygdala (LA) is a key site of plasticity of fear learning, and inhibitory GABAergic circuits in the LA play an important role in the regulation of fear memory and its extinction by controlling projection neuron activities. GABAergic neurons in the LA, like the cerebral cortex, are morphologically, connectionally, electrically and chemically heterogeneous. However, little is know how each subclass of GABAergic neurons serves its functions for amygdaloid circuits. Here we provide the immunohistochemical characterization of calcium-binding protein (parvalbumin, calretinin and calbindin-D28k)-containing GABAergic neurons in the LA , using vesicular GABA transporter (VGAT)-Venus transgenic mice, in which GABAergic neurons are labeled with Venus fluorescent protein. Our results suggest that each subclass of calcium-binding protein-containing GABAergic neurons in the LA might have unique properties for regulating amygdaloid functions.

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