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神経幹・前駆細胞と細胞分化、移植III
Neural Stem/Progenitor Cells and Cellular Differentiation, Transplantation III

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開催日
2010年09月04日(土)
時 間
13:00 - 14:00
会 場
Poster Room 1

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NG2細胞のPETイメージング法の確立
PET imaging of NG2 cells in the adult rat brain

演題番号 : P3-d12

田村 泰久 / Yasuhisa Tamura:1 立花 晃子 / Akiko Tachibana:2 奥山 香里 / Kaori Okuyama:1 林中 恵美 / Emi Hayashinaka:3 和田 康弘 / Yasuhiro Wada:3 高橋 和弘 / Kazuhiro Takahashi:2 片岡 洋祐 / Yosky Kataoka:1 

1:理研 分子イメージング科学研究センター 細胞機能イメージング研究チーム / Cellular Function Imaging Lab., RIKEN Center for Molecular Imaging Science, Kobe 2:理研 分子イメージング科学研究センター イメージング基盤ユニット / Molecular Imaging Integration Unit, RIKEN Center for Molecular Imaging Science, Kobe 3:理研 分子イメージング科学研究センター 分子プローブ動態応用研究チーム / Molecular Probe Dynamics Lab., RIKEN Center for Molecular Imaging Science, Kobe 

 

NG2 cells are ubiquitously distributed throughout the gray and white matter in the brain. NG2 cells undergo cell division and can generate oligodendrocytes and astrocytes as well as neurons even in the adult brain. It is known that NG2 cells become rapidly activated with their morphological changes including hypertrophy of the cell body and processes, and proliferate in response to several brain insults including traumatic injury, excitotoxic lesions and viral infections. Thus, establishment of in vivo imaging technique of NG2 cells could help us evaluate the extent of brain injury and repair processes. In this study, we generated a transgenic rat strain which preferentially overexpressed human estrogen receptorα ligand binding domain (hERL) in the NG2 cells (NG2-hERL Tg rat), and performed PET imaging of the cells in the brain using 16α-[18F]fluoro-17β-estradiol (FES), a PET tracer for hERL.

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