演題番号 : P1-r17
野田 朋裕 / Tomohiro Noda:1 石井 信 / Shin Ishii:1 前田 新一 / Shinichi Maeda:1
1:京都大院 情 システム科学 / Dept Systems Science, Univ of Kyoto, Kyoto
Optical microscopy has been an important tool in neurobiology because it enables us to observe molecules in living cells. However, nano-scale imaging definitely suffers from blur due to diffraction of light passing through the lens. Conventionally, the Rayleigh's criterion has been known as such a two-point resolution of microscope that quantifies the blur caused by Fraunhofer diffraction. Although the Rayleigh's criterion gives us a practical criterion of the resolution limit of two-point sources in a deterministic way, it neglects the stochastic nature of the optical imaging processes. For instance, the diffraction itself is a stochastic diffusion process of photons, and the measurement of photons is also disturbed by stochastic fluctuation such as shot noise. In the existing studies (Ram, et al., 2006; Shahram and Milanfar, 2006), these stochastic aspects are just neglected or inappropriately treated.