The neurons which contain armatic L-amino aced decarboxylase (AADC), and are non-dopaminegic and non-serotonergic are called D-neurons (Jaeger et al. 1983). "D" indicates decarboxylation. They take up precursors of monoamines and decarboxylate them to monoamines, D-neurons also synthesize trace amines including phenylethlamine (PEA) as well as tyramine, as AADC is the rate-limiting synthesizing enzyme for trace amine synthesis. In the postmortem brains of patients with schizophrenia contained lower amount of D-neurons in the striatum and nucleus accumbens. In the nucleru acuumbensshowed reduction in number in the striatum