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Poster Sessions

統合失調症I
Schizophrenia I

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開催日
2010年09月02日(木)
時 間
13:00 - 14:00
会 場
Poster Room 2

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神経精神疾患の病態におけるD-ニューロンの役割
What do D-neurons do in pathogenesis of neuropsychiatric disorders?

演題番号 : P1-p12

池本 桂子 / Keiko Ikemoto:1 北浜 邦夫 / Kunio Kitahama:2 西 克治 / Katsuji Nishi:3 永津 郁子 / Ikuko Nagatsu:4 

1:福島県立医科大学医学部 神経精神医学講座 / Department of Neuropsychiatry, Fukushima Medical University School of Medicine 2:東京都精神医学総合研究所 / Tokyo Metropolitan Institute of Psychiatry, Tokyo, Japan 3:滋賀医科大学法医学講座 / Department of Legal Medicine, Shiga University of Medical Science, Otsu Japan 4:藤田保健衛生大学医学部解剖学講座 / Fujita Health University, School of Medicine, Toyoake, Japan 

 

The neurons which contain armatic L-amino aced decarboxylase (AADC), and are non-dopaminegic and non-serotonergic are called D-neurons (Jaeger et al. 1983). "D" indicates decarboxylation. They take up precursors of monoamines and decarboxylate them to monoamines, D-neurons also synthesize trace amines including phenylethlamine (PEA) as well as tyramine, as AADC is the rate-limiting synthesizing enzyme for trace amine synthesis. In the postmortem brains of patients with schizophrenia contained lower amount of D-neurons in the striatum and nucleus accumbens. In the nucleru acuumbensshowed reduction in number in the striatum

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