演題番号 : P1-p10
肥田 裕丈 / Hirotake Hida:1 毛利 彰宏 / Akihiro Mouri:2 安藤 雄 / Yu Ando:1 鍋島 俊隆 / Toshitaka Nabeshima:2 野田 幸裕 / Yukihiro Noda:1
1:名城大院・薬・病態解析学 / Div of Clinl Sci and Neuropsychopharm, Meijo Univ Grad Sch of Pharm, Nagoya 2:名城大院・薬・薬品作用学 / Dept of Chem Pharm, Meijo Univ Grad Sch of Pharm, Nagoya
Viral infection during neurodevelopment is involved in the etiology of psychiatric diseases including schizophrenia. There is a high prevalence of substance use disorder in first-episode schizophrenia. To examine whether the combination of a neonatal viral infection with an adolescent substance use affect on psychological function in adult, we subjected behavioral tests to adult C57/BL6J mice, which were treated with polyriboinosinic-polyribocytidylic acid (polyI:C; an inducer of strong innate immune responses) at a dose of 5mg/kg during neonatal period (postnatal day 2-6) and with phencyclidine (PCP) at a dose of 10mg/kg during adolescent period (postnatal day 35-41). We demonstrated that neonatal polyI:C treatment exacerbated PCP-induced behavioral phenotypes in sensitization in hyperlocomotion, impulsiveness in a cliff avoidance test, social deficit in a social interaction test and object recognition impairment in a novel object recognition test. These results suggest that neonatal polyI:C injection exacerbates PCP-treated behavioral phenotypes in adult.