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Award Lecture

Tsukahara Award Lecture

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開催日
2010年09月02日(木)
時 間
14:00 - 14:35
会 場
Room 1
Chairperson(s)
笹井 芳樹 / Yoshiki Sasai (理化学研究所 発生・再生科学総合研究センター / RIKEN Center for Developmental Biology)

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胎生期大脳新皮質神経幹細胞の運命制御
Temporal regulation of neural stem cell fate developing mouse neocortex

演題番号 : AL1-1

後藤 由季子 / Yukiko Gotoh:1 Yusuke Hirabayashi:1 Nao Suzki:1 

1:東京大学分子細胞生物学研究所 / Institute of Molecular and Cellular Biosciences, University of Tokyo 

 

One of the fundamental questions in understanding tissue development is how multipotent progenitors/tissue stem cells give rise to various cell types in a defined order to achieve appropriate tissue organization. Neural stem cells (NSCs) attract much attention since these cells give rise to neuronal and glial cell types in a developmental-stage dependent manner with a striking precision. In this study, we have shown that polycomb group (PcG) complex-mediated epigenetic mechanism plays a pivotal role in driving fate switching of NSCs during the mouse neocortical development. We would like to propose that PcG proteins serve as a developmental timer in NSCs.

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