演題

Surgery of the primary tumor in patients with metastatic breast cancer.

[演者] 岩熊 伸高:1
[著者] 唐 宇飛:1, 三島 麻衣:1, 高橋 宏樹:1, 古川 実奈:1, 藤井 輝彦:2, 赤木 由人:1
1:久留米大学外科, 2:久留米大学集学治療センター

Background: Approximately 10% of women newly diagnosed with breast cancer have stage IV disease. Surgery of the primary tumor usually is not advised for patients with metastatic breast cancer at diagnosis because the disease is considered incurable. Recently multiple studies have suggested that resection of the primary tumor improves survival in patients with stage IV breast cancer. But the optimal local management of those patients is controversial.Methods: We reviewed patients with primary breast cancer and concurrent distant metastases seen at our hospital between 2002 and 2014. Demographic and treatment data were collected. We have examined the surgery of primary tumor, and its impact on survival in patients presenting with stage IV breast cancer.Results: A total of 30 patients with stage IV disease were identified in our hospital during this period, and 28 patients (93.3%) underwent total mastectomy. The 28 patients with surgery had a median follow-up of 45.6 months (range: 8-154 months). Their intrinsic subtypes were 11 Luminal types, 13 Luminal-HER2 types, 3 HER2 types and 1 triple negative type. Visceral metastases were diagnosed in 13 patients (46.4%). Bone metastases were diagnosed in 16 patients (57.1%). The median overall survival was 67.2 months. Conclusion: The median overall survival was equivalent to the other studies. Our studies demonstrated that local surgery improved overall survival of patients with metastases breast cancer. But case selection bias may exist to account for the improved survival observed.
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