演題

IS-9-1

Clinical significance of RAB11A expression in human lung squamous cell carcinoma

[演者] 東 陽子:1
[著者] 茂木 晃:1, 横堀 武彦:1, 飯島 岬:1, 小野里 良一:1, 矢島 俊樹:1, 桑野 博行:1
1:群馬大学病態総合外科

Background: In human non-small cell lung cancers, development of various therapeutic agents have provided benefits to the patients with adenocarcinoma, but not for with squamous cell carcinoma (SQCC). The novel therapeutic targets are required for patients with SQCC. We re-analyzed the database of the gene profiling of 129 SQCC patients (Raponi et al. GDS 2373), and chose RAB11A as candidate for a prognostic factor and a therapeutic target in SQCC. RAB11A small GTPases is dominantly localized at recycling endosome, and regulates the surface expression of various receptors and proteins via intracellular trafficking in normal cells. In several cancer cells, RAB11A has been demonstrated to play a key role in the cell migration and proliferation through the modulation of integrin and EGFR recycling. The purpose of this study was to clarify the clinical significance of RAB11A in SQCC.Materials and Methods: RAB11A expression was analyzed by immunohistochemistry in 84 SQCC patients, and functional analysis of RAB11A was performed by proliferation assay. Results: High expression of RAB11A was correlated with the aggressiveness of the tumor, and also with poor prognosis in SQCC patients. Furthermore, cellular proliferative potential and EGFR expression were suppressed in RAB11A-knockdown SQCC cell lines. Conclusion: Our data demonstrated that RAB11A expression in SQCC could be a useful prognostic marker, and that RAB11A might represent a novel therapeutic target for SQCC via inhibition of tyrosine kinase receptor recycling, such as EGFR.
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