演題

IS-8-6

Predictive factors of malignant intraductal papillary mucinous neoplasm of the pancreas

[演者] 鈴村 和大:1
[著者] 麻野 泰包:1, 小坂 久:1, 飯室 勇二:1, 平野 公通:1, 岡田 敏弘:1, 宇山 直樹:1, 中村 育夫:1, 近藤 祐一:1, 裴 正寛:1, 末岡 英明:1, 矢田 章人:1, 大橋 浩一郎:1, 岡本 共弘:1, 栗本 亜美:1, 藤元 治朗:1
1:兵庫医科大学外科

[Background/Aims] Preoperative determination of malignancy in intraductal papillary mucinous neoplasms (IPMN) remains problematic. The aim of this study was to review our experience with surgical resection for IPMN and to identify the clinicopathological features that predicted malignancy in IPMN. [Methods] Twenty-six patients with IPMN who underwent surgical resection during January 2004 to December 2013, were retrospectively analyzed. Adenoma and borderline pathology were considered to be benign disease, whereas carcinoma in situ and IPMN with invasive carcinoma were considered as malignant. [Results] There were 12 men and 14 women, with a mean age of 70 years. Ten patients (38%) had benign IPMN and 16 (62%) patients had malignant IPMN. Serum carbohydrate antigen 19-9 (CA19-9) value>8.5 U/ml and serum S-Pancreas-1 antigen (SPan-1) value>5.7 U/ml were predictive of malignant IPMN by univariate analysis, and serum SPan-1value>5.7 U/ml was identified as the only independent predictive factor for malignancy (P=0.025, Odds ratio, 15; 95% confidence interval, 1.4-161.1). [Conclusion] Serum SPan-1 value>5.7 U/ml was a significant predictor of malignant IPMN.
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