演題

Effects of weight loss and diabetes improvement and the underlying mechanisms after sleeve gastrectomy

[演者] 山本 寛:1
[著者] 貝田 佐知子:1, 赤堀 浩也:1, 太田 裕之:1, 山口 剛:1, 園田 寛道:1, 清水 智治:1, 塩見 尚礼:1, 村田 聡:1, 仲 成幸:1, 谷 眞至:1
1:滋賀医科大学消化器外科

It is well known that bariatric surgery not only reduces body weight but also dramatically improves obesity related diseases including diabetes, and the surgery to be aimed for improving metabolic diseases is specifically called metabolic surgery. The underlying mechanisms of improved glycemic control after surgery has not been undetermined yet.In Japan, laparoscopic sleeve gastrectomy (LSG) has become eligible for insurance reimbursement in 2014. LSG has been reported to have considerable effects of weight loss and improved glycemic control. We performed LSG for 34 morbid obese patients and had good results in diabetic improvement as well as in body weight loss. Body weight was significantly decreased after LSG in all cases. HbA1c was markedly decreased and great improvement of glucose tolerance with enhancement of insulin and GLP-1 secretion during OGTT was observed in all diabetic patients. We also found markedly increased intestinal motility nicely correlated to GLP-1 secretion after OGTT (PLOS one 2013). In addition, we recently showed the role of neuronal system of the portal vein in maintaining normal glucose metabolism (Peptides 2013) and the role of different segments of gastrointestinal tract on glucose metabolism (J invest Surg 2014) in rats. In this presentation, we will summarize the several possible mechanisms of improved glycemic control after LSG with recent reports and our data.
詳細検索
アプリバナー iPhone版,iPad版 Android版