演題詳細

ポスター / Poster

ポスター 51 (Poster 51) :小児血液 (Pediatric Blood)

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日程
2013年10月11日(金)
時間
16:50 - 17:50
会場
ポスター会場 / Poster (ロイトン札幌 3F エメラルドABCD)
座長・司会
遠藤 幹也 (Mikiya Endo):1
1:岩手医科大学 小児科学講座
 
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Limitation of evaluation for leukemia by FDG-PET

演題番号 : PS-1-389

竹内 正宣 (Masanobu Takeuchi):1、佐々木 康二 (Koji Sasaki):1、横須賀 とも子 (Tomoko Yokosuka):1、柳町 昌克 (Masakatsu Yanagimachi):1、梶原 良介 (Ryosuke Kajiwara):1、三宅 暁夫 (Akio Miyake):2、大橋 健一 (Kenichi Ohashi):2、横田 俊平 (Shumpei Yokota):1

1:Pediatrics,Yokohama City University Hospital,Japan、2:Anatomic and Clinical Pathology Department,Yokohama City University Hospital,Japan

 

FDG-PET has been widely used to assist diagnosis and evaluate response to therapy in malignancies. However, evaluation for acute lymphoblastic leukemia by FDG-PET after treatment has not previously been reported. We report a case in which FDG-PET uptake was observed in his bilateral femoral bone at the end of the treatment, however bone biopsy showed no evidence of leukemia cell. 5-years-old boy was diagnosed with pre B-cell acute lymphoblastic leukemia in 2008, and was treated with TCCSG-ALL-04 protocol. Two years after the end of maintenance therapy, the patient had bilateral knee pain. The hematological examination revealed 3.5% blast cell in his peripheral blood. The bone marrow aspirationrevealed 70% lymphoblast. The FDG-PET examination showed diffuse uptake in the thigh, tibia and patella. The patient was diagnosed with relapsed acute lymphoblastic leukemia, and treated immediately with JPLSG ALL R-08 protocol. After the induction therapy, we confirmed the molecular complete remission. The FDG-PET examinations after the intensive treatment showed reduced FDG-PET uptake, but slight FDG-PET uptake remained in the thigh and tibia. We suspected the persistence of leukemia because of the FDG-PET findings. The bone biopsy was performed and revealed no leukemic cell. This is apparently the first case report with the comparative investigation comparing FDG-PET uptake value and pathological findings. This suggests that uptake values of FDG-PET are not always matched with disease status of ALL, and limitation of FDG-PET scan should be carefully considered

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