演題詳細

ポスター / Poster

ポスター 49 (Poster 49) :ウイルス感染症

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日程
2013年10月11日(金)
時間
16:50 - 17:50
会場
ポスター会場 / Poster (ロイトン札幌 3F エメラルドABCD)
座長・司会
古川 雄祐 (Yusuke Furukawa):1
1:自治医科大学分子病態治療研究センター 幹細胞制御研究部
 
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Possible reactivation of occult hepatitis C virus infection after R-CHOP therapy

演題番号 : PS-1-375

宮下 要 (Kaname Miyashita):1、本郷 優衣 (Yui Hongo):2、迫田 哲平 (Teppei Sakoda):1、中島 明彦 (Akihiko Nakashima):3、森園 周祐 (Shusuke Morizono):4、東 宣彦 (Nobuhiko Higashi):4,5

1:Dept. Haematology and Chemotherapy, Saiseikai Fukuoka General Hospital, Fukuoka, Japan、2:Dept. Diabetes and Endocrinology, Saiseikai Fukuoka General Hospital, Fukuoka, Japan、3:Dept. Histopathology, Saiseikai Fukuoka General Hospital, Fukuoka, Japan、4:Dept. Hepatology, Saiseikai Fukuoka General Hospital, Fukuoka, Japan、5:Dept. Internal Medicine, Social Insurance Nogata Hospital, Nogata, Japan

 

Occult hepatitis C virus (HCV) infection has been found in anti-HCV antibody (HCV-Ab) -negative and serum HCV RNA-negative patients with abnormal results of liver function tests (LFT) of unknown origin or in patients with spontaneous or treatment-induced HCV RNA clearance from serum. It is unknown whether reactivation of occult HCV infection can occur after chemotherapy. We report here a case of possible reactivation of occult HCV infection after R-CHOP therapy. A 79 year-old male patient with follicular lymphoma (grade 3a) received R-CHOP therapy from January 2012. The patient had a past history of liver dysfunction (LD) of unknown origin approximately 20 years before. No abnormal results of LFT nor HCV-Ab existed at the start of the treatment. Mild LD occured after R-CHOP therapy, and LD was exacerbated after the fifth cycle of the therapy. No aetiology for LD including HCV-Ab was detected at that time. R-CHOP therapy was, therefore, discontinued as drug-induced LD. However, marked ascites appeared 6 month later in November 2012. Liver cirrhosis was proved by imaging study at this time. Moreover, no HCV-Ab was detected, while serum HCV RNA was detected by real time PCR (7.5 log copy/ml). No blood transfusion nor sexual activity had been performed during the treatment. From these results, it was suggested that reactivation of occult HCV infection might occur. The patient finally died from hepatic failure in December 2012. From our experience, it might be better to note that reactivation of occult HCV infection may exist if LD of unknown origin occurs during R-CHOP therapy.

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