演題詳細

一般口演 / Oral Session

一般口演 108 (Oral Session 108) :感染症・その他

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日程
2013年10月13日(日)
時間
16:00 - 17:00
会場
第14会場 / Room No.14 (札幌市教育文化会館 3F 研修室305)
座長・司会
岩崎 博道 (Hiromichi Iwasaki):1
1:福井大学医学部 感染制御部
 
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Prediction of transplant-related complications by procalcitonin levels before allogeneic HCT

演題番号 : OS-3-188

佐藤 美樹 (Miki Sato):1、仲宗根 秀樹 (Hideki Nakasone):1、赤星 佑 (Yu Akahoshi):1、中野 裕史 (Hirofumi Nakano):1、鵜飼 知嵩 (Tomotaka Ugai):1、和田 英則 (Hidenori Wada):1、山崎 諒子 (Ryoko Yamasaki):1、石原 優子 (Yuko Ishihara):1、坂本 佳奈 (Kana Sakamoto):1、河村 浩二 (Koji Kawamura):1、蘆澤 正弘 (Masahiro Ashizawa):1、町島 智人 (Tomohito Machishima):1、斉藤 桐子 (Kiriko Saito-Terasako):1、木村 俊一 (Shun-Ichi Kimura):1、菊地 美里 (Misato Kikuchi):1、谷原 亜紀 (Aki Tanihara):1、山崎 理絵 (Rie Yamazaki):1、田中 ゆきえ (Yukie Tanaka):1、諫田 淳也 (Junya Kanda):1、賀古 真一 (Shinichi Kako):1、西田 淳二 (Junji Nishida):1、神田 善伸 (Yoshinobu Kanda):1

1:Division of Hematology, Saitama Medical Center, Jichi Medical University

 

[Background]We previously reported that the baseline C-reactive protein (CRP) level didn't predict infectious events after allogeneic hematopoietic cell transplantation (allo-HCT). In this study, we focused on the baseline serum procalcitonin (PCT) level to predict infectious complications.
[Patients and methods]We retrospectively analyzed 79 recipients who received allo-HCT between 2008 and 2012. We evaluated the predictive value of baseline PCT level for early documented infection (DI) and early blood stream infection (BSI) by receiver-operating characteristic (ROC) curve analysis.
[Result]There were 45 males and 34 females with a median age of 45 years. The median PCT level before the start of the conditioning regimen was 0.04 ng/ml (range 0.00-0.73 ng/ml). DI and BSI were observed in 23 and 18 patients, respectively, within 30 days after allo-HCT. The areas under the ROC curves (AUCs) were 0.60 for early DI and 0.61 for early BSI. Using a cut-off at 0.07 ng/ml , cumulative incidences of DI and BSI at day 30 after allo-HCT were 21.2% vs 44.4% (P=0.038), and 15.4% vs 37.0% (P=0.035). In multivariate analysis, the baseline PCT level was associated with DI (HR 2.01, P=0.089) and BSI (HR 2.28, P=0.084) at borderline significance. The predictive impacts of PCT and CRP levels for DI and BSI were similar in the current cohort. With regard to non-relapse mortality, the baseline CRP level appeared to be a superior predictor to the PCT level.
[Conclusion]We could not conclude that baseline PCT level was a suitable predictive biomarker for the infectious events after allo-HCT.

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