演題詳細

ポスター / Poster

ポスター 36 (Poster 36) :骨髄腫:その他

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日程
2013年10月11日(金)
時間
16:50 - 17:50
会場
ポスター会場 / Poster (ロイトン札幌 3F ロイトンホールABCD)
座長・司会
池田 宇次 (Takashi Ikeda):1
1:静岡県立静岡がんセンター 血液・幹細胞移植科
 
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Analysis of infection profile in multiple myeloma patients treated with bortezomib and lenalidomide

演題番号 : PS-1-272

久納 俊祐 (Shunsuke Kunou):1、村瀬 江里 (Eri Murase):1、牛田 宣 (Sen Ushida):1、牛島 洋子 (Yoko Ushijima):1、青木 智広 (Tomohiro Aoki):2、北村 邦郎 (Kunio Kitamura):1

1:Ichinomiya municipal hispital、2:Japanese Red Cross Nagoya Daini Hospital

 

[Purpose]Herpes zoster(HZ) is the most common infection in bortezomib treatment for the multiple myeloma(MM). This study aimed to compare the incidence of HZ and the infection profile between bortezomib(Bor) and lenalidomide(Len).[Methods]62 MM patients (median age 66 years) treated with Bor or Len containing regimens between Mar.2007 and Mar.2013 were analyzed for the infection episodes. Acyclovir(ACV) prophylaxis (continuous oral 200mg/day administration without cessation) was used according to the respective physicians at the beginning and used for all patients in Bor treatment after noticing an increased incidence. ACV was not prophylactically administered in Len treatment. [Results]Bor was administered to 56 cases, comprising of 16 in ACV non-prophylaxis group and 40 in prophylaxis group. Len was administered to 38 cases. Six of 56 (10.7%) treated with Bor and 1 of 38(2.6%) treated with Len developed HZ, showing trend of higher incidence in Bor (p=0.235).All 6 patients who developed HZ during Bor treatment did not receive ACV prophylaxis (37.5%, 6/16 vs 0%, 0/40)(p=0.002).Other Infection except HZ included pneumonia(n=11) ,herpes simplex(n= 4),febrile neutropenia(n= 4), sepsis(n=3),and the others(n=3 ). The number of patients who needed hospitalization due to infection was 11 in Len and 10 in Bor (29.0% vs 18.0%,p=0.205). [Conclusion] HZ is the complication distinctive to Bor treatment and oral ACV 200mg/day prophylaxis is effective and sufficient in preventing HZ. Len seems not to increase HZ, but tended to increase other infection.

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