演題詳細

ポスター / Poster

ポスター 35 (Poster 35) :骨髄腫:症例(レナリドミド)

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日程
2013年10月11日(金)
時間
16:50 - 17:50
会場
ポスター会場 / Poster (ロイトン札幌 3F ロイトンホールABCD)
座長・司会
和泉 透 (Tohru Izumi):1
1:栃木県立がんセンター 血液内科
 
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Two cases of multiple myeloma treated with lenalidomide for their relapses after allogeneic SCT

演題番号 : PS-1-263

塚田 信弘 (Nobuhiro Tsukada):1、新垣 清登 (Sumito Shingaki):1、宮崎 寛至 (Kanji Miyazaki):1、阿部 有 (Yu Abe):1、関根 理恵子 (Rieko Sekine):1、中川 靖章 (Yasunori Nakagawa):1、鈴木 憲史 (Kenshi Suzuki):1

1:Division of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan

 

We report two cases treated with lenalidomide (Len) for their relapses after allo-SCT. [case 1] 38 years old woman was diagnosed with multiple myeloma (IgG-κ, ISS 1) in 2007. She was treated with local irradiation and systemic chemotherapy, but she experienced breast plasmacytoma after 2 years. Bortezomib was not effective and ASCT was performed. After 3 months, she underwent uCBT (Flu+Mel+TBI). CR was maintained for 2 years, but she experienced chest pain and IgG elevation. PET/CT revealed accumulation in her rib and iliac bone. The effect of bortezomib was limited even after 2 cycles. Len was started (25mg/day for 21 days) and IgG dramatically decreased after 1 cycle. After 6 cycles of Len, she obtained stringent CR with negative PET/CT. She is staying in sCR 6 months after the end of Len treatment. [case2] 48 year old woman was diagnosis as multiple myeloma (IgA-κ, ISS 1) in 2007. She was treated with thalidomide followed by bortezomib, resulting in VGPR. After 9 months, she relapsed and ASCT was performed in Mar. 2011. After 6 months, allo-PBSCT from HLA-matched sibling was performed (Flu+Mel). After 9 months, her IgA increased and clonal plasma cells were detected. Len was started with 25mg/day. Her IgA increased even after 6 cycles of treatment, and treatment had to be changed. In both cases, 6 cycles of Len 25mg/day were completed and GVHD was not induced, suggesting the feasibility of Len after allo-SCT in specific setting. In the successful case, i) Len was never used before relapse, ii) relapse after 2 years from SCT, iii) transplantation from unrelated donor.

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