演題詳細

ポスター / Poster

ポスター 31 (Poster 31) :ATL:移植モガムリズマブ

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日程
2013年10月11日(金)
時間
16:50 - 17:50
会場
ポスター会場 / Poster (ロイトン札幌 3F ロイトンホールABCD)
座長・司会
今泉 芳孝 (Yoshitaka Imaizumi):1
1:長崎大学病院 血液内科
 
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A case of adult T cell leukemia/lymphoma with eosinophilia

演題番号 : PS-1-236

有馬 直佑 (Naosuke Arima):1、井上 大栄 (Hirosaka Inoue):1、久木田 稔正 (Toshimasa Kukita):1、松元 正 (Tadashi Matsumoto):1

1:Dept. of Hematology, Jiaikai Imamura Hospital, Kagoshima, Japan

 

Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-lymphoproliferative disorder that manifest multifacet clinical and laboratory changes. Eosinophilia, one of the complications of ATL, occurs in about 20% of ATL patients. We present a case of ATL with remarkable eosinophilia which was resolved with chemotherapy for ATL. A 75-year-old male was admitted to our hospital for leukocytosis with eosinophilia and lymphoadenopathy. Hypereosinophilic syndrome, chronic eosinophilic leukemia and allergic reaction were ruled out. Lymph node biopsy revealed T cell lymphoma with HTLV-1 provirus monoclonal integration, resulted in a diagnosis of ATL. Since the number of eosinophils having normalized in response to the medical treatment of ATL and the increased levels of serum IL-5 were revealed, the eosinophilic-leukocytosis accompanied with ATL was considered. The similar chromosomal abnormality pattern was obtained from lymph node and bone marrow aspiration specimen. Bone marrow infiltration of ATLL may have facilitated the eosinophilic leukocytosis.

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