演題詳細

ポスター / Poster

ポスター 30 (Poster 30) :リンパ腫:AITL・皮膚リンパ腫

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日程
2013年10月11日(金)
時間
16:50 - 17:50
会場
ポスター会場 / Poster (ロイトン札幌 3F ロイトンホールABCD)
座長・司会
内田 俊樹 (Toshiki Uchida):1
1:名古屋第二赤十字病院 血液・腫瘍内科
 
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A case of mycosis fungoides with rapid progression of pulmonary invasion

演題番号 : PS-1-229

太良 史郎 (Shiro Tara):1、藤本 哲広 (Tetsuhiro Fujimoto):1、下村 泰三 (Taizo Shimomura):1、鈴島 仁 (Hitoshi Suzushima):1

1:Hematology Department, Kumamoto Shinto General Hospital, Kumamoto, Japan

 

Mycosis fungoides(MF) is a low grade T cell lymphoma that grows over 10 years. The tumor cells infiltrate into lymph nodes or internal organs only at the late stage. We present here a case of MF with rapid progression of pulmonary invasion after 3 years from the onset of skin eruption.
29 year-old previously healthy woman noticed skin eruption at her left mouth angle 3 years before her admission to our hospital. Next year, she visited former clinic and was diagnosed as follicular mucinosis. One month before admission, she complained of multiple cervical lymphadenopathy, low grade fever, and dry cough. Chest X-ray showed bilateral mild ground grass opacity (GGO) and, then, cervical lymph node and skin biopsy were performed. Two weeks after the biopsy, her respiratory symptoms worsened and introduced to our department. On admission, she was in respiratory failure and chest X-ray showed rapid exacerbation of GGO. Close investigation revealed the CD4 positive T lymphocyte invasion to the lymph node, skin, and lung. T cell receptor (TCR) gene rearrangement was detected in her lymph node sample. We diagnosed as MF with pulmonary invasion (T3N3M1B0, stage IV) and started chemotherapy. Her respiratory symptoms and chest X-ray abnormality were improved with one course of EPOCH therapy. Although we cannot prove the onset of this case due to lack of examination of T-cell clonality, we believe that our case developed to advanced stage in only 3 years. We should pay attention to pulmonary involvement of MF even within a few years from the onset.

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