演題詳細

ポスター / Poster

ポスター 30 (Poster 30) :リンパ腫:AITL・皮膚リンパ腫

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日程
2013年10月11日(金)
時間
16:50 - 17:50
会場
ポスター会場 / Poster (ロイトン札幌 3F ロイトンホールABCD)
座長・司会
内田 俊樹 (Toshiki Uchida):1
1:名古屋第二赤十字病院 血液・腫瘍内科
 
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Poikilodermatous mycosis fungoides with a CD8+ CD56+ immunophenotype

演題番号 : PS-1-227

岡 大五 (Daigo Oka):1、山本 剛伸 (Takenobu Yamamoto):2、塩見 達志 (Tatsushi Shiomi):3、物部 泰昌 (Yasumasa Monobe):4、定平 吉都 (Yoshito Sadahira):1

1:Department of Pathology.1,Kawasaki Medical School,Kurashiki、2:Department of Dermatology,Kawasaki Medical School,Kurashiki、3:Division of Organ Pathology,Tottori University,Tottori、4:Department of Pathology,Kawasaki Medical School,Kawasaki Hospital,Okayama

 

Mycosis fungoides (MF) represents the most common type of cutaneous lymphoma. MF shows varieties in both its clinical presentation and immunophenotype. We herein report one case of poikilodermatous MF with a CD8+ CD56+ immunophenotype and present a literature review. A 20-year-old Japanese woman presented with a 10-year history of multiple poikilodermatous and reddish or brownish patches with mild pruritus on the chest, abdomen, back, buttock and thighs. Histopathologically, small- to medium-sized atypical lymphocytes infiltrated into the epidermis, indicating epidermotropism, along the basal layer, and distributed in band-like appearance in the papillary dermis. Immunohistochemically, atypical lymphocytes expressed CD3, CD8, CD56, T-cell intracellular antigen (TIA)-1, granzyme B and beta F1 but lacked expression of CD4, CD20, CD30 and Epstein-Barr virus (EBV) latent membrane protein 1. An EBV-encoded small non-polyadenylated RNA-1 (EBER-1) signal was not detected. On the basis of these findings, the diagnosis of CD8+ CD56+ MF was established. Poikilodermatous MF with a CD8+ CD56+ immunophenotype, as presented herein, is extremely rare. Although further investigation is needed to fully clarify the nature of this aberrant phenotype of MF, we stress that it is important to recognize this rare immunophenotype of MF to distinguish it from aggressive cytotoxic cutaneous lymphomas.

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