演題詳細

ポスター / Poster

ポスター 30 (Poster 30) :リンパ腫:AITL・皮膚リンパ腫

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日程
2013年10月11日(金)
時間
16:50 - 17:50
会場
ポスター会場 / Poster (ロイトン札幌 3F ロイトンホールABCD)
座長・司会
内田 俊樹 (Toshiki Uchida):1
1:名古屋第二赤十字病院 血液・腫瘍内科
 
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Massive plasmacytosis in angioimmunoblastic T-cell lymphoma

演題番号 : PS-1-223

名越 久朗 (Hisao Nagoshi):1、古林 勉 (Tsutomu Kobayashi):1、知念 良顕 (Yoshiaki Chinen):1、中山 理祐子 (Ryuko Nakayama):1、清田 実希 (Miki Kiyota):1、前川 紗央梨 (Saori Maegawa):1、佐々木 奈々 (Nana Sasaki):1、水谷 信介 (Shinsuke Mizutani):1、志村 勇司 (Yuji Shimura):1、杉谷 未央 (Mio Sugitani):1、松本 洋典 (Yosuke Matsumoto):1、堀池 重夫 (Shigeo Horiike):1、黒田 純也 (Junya Kuroda):1、谷脇 雅史 (Masafumi Taniwaki):1

1:Div. Hematol. Oncol., Kyoto Pref. Univ. of Med., Japan

 

Massive plasmacytosis (MP) (>2x109/L) is a rare clinical condition which infrequently accompanies with plasma cell dyscracia, lymphoproliferative disorders or autoimmune disorders, and the differential diagnosis of MP has been sometime difficult. In angionimmunoblastic T-cell lymphoma (AITL), while plasmacytes are occasionally observed in peripheral blood, the clinical significance of MP has not been evaluated. We retrospectively analyzed 15 patients with AITL including 3 with MP diagnosed between 1990 and 2012. All 3 patients with MP presented severe systemic symptoms, such as high fever, body weight loss, night sweating, or intractable skin rash. Compared with patients without MP, 3 patients with MP showed poorer performance status (P=0.002), higher levels of total protein (10.2 vs. 7.15 g/dL, P=0.009), IgG (4445 vs. 2185 mg/dL, P=0.009) and IgA (950 vs. 347.5 mg/dL, P=0.014), and lower albumin level (2.4 vs. 3.15 g/dL, P=0.030). Nevertheless, no significant differences were observed in factors associated with tumor burden, such as LDH, soluble interleukin-2 receptor, or sites of involvement, between patients without MP and with MP. Moreover, treatment including combination chemotherapies or immunosuppressive therapy induced rapid resolution of systemic symptoms and durable remission in 3 patients with MP. Collectively, although rare, the immediate and correct diagnosis and the quick initiation of an appropriate treatment lead favorable clinical outcome of AITL with MP, otherwise, AITL patients with MP deteriorate rapidly.

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