演題詳細

一般口演 / Oral Session

【E】一般口演 13 (Oral Session 13) :Malignant Lymphoma:Genomic Alteration

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日程
2013年10月11日(金)
時間
09:30 - 10:30
会場
第9会場 / Room No.9 (ロイトン札幌 1F キャッスル)
座長・司会
渡邊 俊樹 (Toshiki Watanabe):1
1:Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Japan
 
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Alterations of cell cycle-related genes are involved in transformation of chronic ATL

演題番号 : OS-1-63

吉田 稚明 (Noriaki Yoshida):1,2、加留部 謙之輔 (Kennosuke Karube):1、宇都宮 與 (Atae Utsunomiya):3、塚崎 邦弘 (Kunihiro Tsukasaki):4、今泉 芳孝 (Yoshitaka Imaizumi):5、平良 直也 (Naoya Taira):6、鵜池 直邦 (Naokuni Uike):7、海野 啓 (Akira Umino):1,8、在田 幸太郎 (Kotaro Arita):1,9、片山 幸 (Miyuki Katayama):1、都築 忍 (Shinobu Tsuzuki):1、大島 孝一 (Koichi Ohshima):10、瀬戸 加大 (Masao Seto):1,2

1:Div. of Molecular Medicine, Aichi Cancer Center, Nagoya, Japan、2:Dept. of Cancer Genetics, Nagoya University Graduate School, Nagoya, Japan、3:Dept. of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan、4:Dept. of Hematology, National Cancer Center Hospital East, Kashiwa, Japan、5:Hematology and Molecular Medicine Unit, Nagasaki University, Nagasaki, Japan、6:Dept. of Internal Medicine, Heartlife Hospital, Okinawa, Japan、7:Dept. of Hematology, National Kyushu Cancer Center, Fukuoka, Japan、8:Hematology and Oncology, Mie University, Tsu, Japan、9:3rd Dept. of Internal Medicine, University of Toyama, Toyama, Japan、10:Dept. of Pathology, Kurume University, Fukuoka, Japan

 

Adult T-cell leukemia/lymphoma (ATL) is a human T-cell leukemia virus type-1 induced neoplasm and four major clinical ATL subtypes have been identified: acute, lymphoma, chronic and smoldering subtypes. Although the chronic and smoldering subtypes are regarded as indolent ATL, about a half of them progress to acute ATL and subsequently die of disease. In the present study, oligo-array comparative genomic hybridization and gene-expression profiling were applied for 27 cases of chronic ATL and 35 cases of acute ATL in an effort to delineate the molecular pathogeneses involved in transformation. The results revealed that CDKN2A located on 9p21.3 is significantly associated with acute ATL but chronic ATL. The Tet-Off ATL cell lines were subsequently established for functional analyses. Re-expression of CDKN2A (especially INK4a) suppressed the proliferation of ATL cell lines. CDKN2A is a well-known cell cycle regulator, therefore, the chronic ATL patients were analyzed on cell cycle regulators. It was found that chronic ATL patients could be divided into two groups according to the existence of genomic alterations in cell cycle-related genes. Interestingly, the group having alterations with these genes showed a poorer prognosis than the group without such alterations. These findings indicated that cell cycle-related genes are important in acute transformation of chronic ATL and should serve as good prognostic markers for chronic ATL.

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