演題詳細

ポスター / Poster

ポスター 18 (Poster 18) :成人ALL:症例

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日程
2013年10月11日(金)
時間
16:50 - 17:50
会場
ポスター会場 / Poster (ロイトン札幌 3F ロイトンホールABCD)
座長・司会
杉浦 勇 (Isamu Sugiura):1
1:豊橋市民病院 血液・腫瘍内科
 
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BCR/ABL positive acute leukemia experienced in our hospital during two months

演題番号 : PS-1-131

小杉 信晴 (Nobuharu Kosugi):1、岩崎 寿代 (Hisayo Iwasaki):2

1:Department of Hematology, Numazu City Hospital, Shizuoka, Japan、2:Department of Clinical Laboratory, Numazu City Hospital, Shizuoka, Japan

 

BCR/ABL fusion gene located in the Philadelphia (Ph) chromosome is categorized major, minor or micro by the breakpoint region on BCR gene. Most of BCR/ABL positive leukemia is chronic myelogenous leukemia (CML), but is observed in a part of acute lymphoid leukemia (ALL) or acute myeloid leukemia (AML). We had three different cases of BCR/ABL positive acute leukemia in a short span of two months. Case1 : A 31-year-old woman came to our hospital in December 2012 because of leukocytosis with blasts, anemia and thrombocytopenia. Myeloperoxidase (MPO) was negative in blasts. RQ-PCR for major BCR/ABL in bone marrow (BM) was positive. But fluorescence in situ hybridization (FISH) for BCR/ABL in neutrophils was negative. Therefore she was diagnosed as major BCR/ABL positive ALL. Case2 : A 67-year-old man came in December 2012 because of fever and thrombocytopenia. MPO negative blasts increased in BM and RQ-PCR for minor BCR/ABL was positive. He was diagnosed as minor BCR/ABL positive ALL. Case3 : A 77-year-old woman came in February 2013 because of leukocytosis with blasts, anemia and thrombocytopenia. MPO was positive in blasts and RQ-PCR for minor BCR/ABL was positive. However FISH for BCR/ABL in neutrophils was positive. Therefore she was diagnosed as minor BCR/ABL positive CML blastic crisis. All cases were treated with combination chemotherapy with dasatinib and acquired complete remission. It is not unusual for BCR/ABL+ALL or CML-BC and they are almost minor BCR/ABL and major BCR/ABL respectively. But we had major BCR/ABL+ALL and minor BCR/ABL+CML-BC during two months.

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