演題詳細

ポスター / Poster

ポスター 18 (Poster 18) :成人ALL:症例

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日程
2013年10月11日(金)
時間
16:50 - 17:50
会場
ポスター会場 / Poster (ロイトン札幌 3F ロイトンホールABCD)
座長・司会
杉浦 勇 (Isamu Sugiura):1
1:豊橋市民病院 血液・腫瘍内科
 
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A case of T lymphoblastic leukemia/leukemia with t(7;14)(p15;q32)

演題番号 : PS-1-127

島田 麻美 (Asami Shimada):1,2、杉元 啓二 (Kei-Ji Sugimoto):1、吉川 仁美 (Hitomi Yoshikawa):1、松澤 奈々 (Nana Matsuzawa):1、大谷 慧 (Satoshi Ohtani):1、稲野 資明 (Tadaaki Inano):1、山口 奈苗 (Nanae Yamaguchi):1、岡野 美樹子 (Mikiko Okano):1、若林 陸 (Mutsumi Wakabayashi):1、今井 英則 (Hidenori Imai):1、関口 康宣 (Yasunobu Sekiguchi):1、小松 則夫 (Norio Komatsu):2、野口 雅章 (Masaaki Noguchi):1

1:Department of Hematology, Juntendo University Urayasu Hospital, Chiba, Japan、2:Department of Hematology, Juntendo University, Tokyo, Japan

 

[Introduction] We report a case of T-lymphoblastic leukemia/lymphoma (T-LBL) with a t(7;14)(p15;q32) chromosomal aberration. [Case Report] The patient was a 22-year-old male who came to our hospital in December 2011 after noticing a swollen lymph node on the left side of his neck. A lymph node biopsy was performed, and reactive lymphadenitis was suspected. A bone marrow examination was performed in February 2012, and after making a diagnosis of T-LBL, remission-induction therapy was started. The blast cells in the bone marrow exhibited a cytoplasmic CD3+, surface CD3-, CD5+, CD4-, and CD8- immature thymocytic pattern. Another lymph node biopsy was performed, and an expression pattern similar to that of the blast cells in the bone marrow was observed. Also, a t(7;14)(p15;q32) chromosome aberration was observed in 3 of the 14 cells that were analyzed. [Discussion] Based on the presence of t(7;14)(p15;q32), according to the literature, it appeared that T-LBL may have developed because the T-cell leukemia 1 (TCL1) gene, which is located at 14q32, was affected by the transcription region of the TCRγ gene, which is located at 7p15. Thus far, 8 cases of T-LBL with a t(7;14)(p15;q32) karyotype have been reported, and it is an immature thymocytic pattern. Although no cases have ever been reported, there may be T-LBL cases that have a translocation of the TCL1 gene and the region TCRα β γ gene region that does not involve TCRγ.

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