演題詳細

ポスター / Poster

ポスター 13 (Poster 13) :MDS:臨床 2

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日程
2013年10月11日(金)
時間
16:50 - 17:50
会場
ポスター会場 / Poster (ロイトン札幌 3F ロイトンホールABCD)
座長・司会
太田 健 (Ken Ota):1
1:弘前大学大学院医学研究科 消化器血液内科学講座
 
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Prognostic impact of the IPSS-R and CD7 expression on myeloblasts in Japanese patients with MDS

演題番号 : PS-1-94

近藤 麻加 (Asaka Kondou):1、田村 秀人 (Hideto Tamura):1,2、猪口 孝一 (Koichi Inokuchi):1、緒方 清行 (Kiyoyuki Ogata):1,2、角元 慶二 (Keiji Kakumoto):2、松田 晃 (Akira Matsuda):2、通山 薫 (Kaoru Tohyama):2、上田 恭典 (Yasunori Ueda):2、黒川 峰夫 (Mineo Kurokawa):2、竹内 仁 (Jin Takeuchi):2、柴山 浩彦 (Hirohiko Shibayama):2、恵美 宣彦 (Nobuhiko Emi):2、泉二 登志子 (Toshiko Motoji):2、宮崎 良秀 (Yoshihide Miyazaki):2、玉置 広哉 (Hiroya Tamaki):2、三谷 絹子 (Kinuko Mitani):2、直江 知樹 (Tomoki Naoe):2、杉山 治夫 (Haruo Sugiyama):2、高久 史麿 (Fumimaro Takaku):2

1:Division of Hematology, Nippon Medical School, Tokyo, Japan、2:WT1 mRNA assay kit MDS research group

 

Introduction: We showed previously that CD7 positivity of MDS blasts was an independent variable for a poor prognosis. Recently, the revised IPSS (IPSS-R), including new prognostic variables of age, performance status, serum ferritin, and lactate dehydrogenase, has been reported. This study aimed to validate the efficacy of the IPSS-R and immunophenotypes of MDS blasts in Japan.Methods & Results: Prognostic variables including the R-IPSS score were evaluated in 81 MDS patients [refractory anemia (RA) 55, RA with ringed sideroblasts 7, RA with excess blasts (RAEB) 18, and RAEB in transformation 1], comprising 50 men/31 women with a median age of 67 (range 27-88) years. Immunophenotyping was performed by 3-color flow cytometry, in which blast cells were gated with a CD45-gating method, and 9 parameters, i.e., CD34+ myeloblast-related and B-progenitor-related cluster size, myeloblast CD45 expression, and aberrant expression of CD7, CD10, CD11, CD15, CD56, and B7-H1 on myeloblasts, were analyzed. Using the Cox proportional hazard regression model, we identified five prognostic variables: IPSS-R score; percentage of blasts in peripheral blood; CD7 expression; gender; and white blood cell count. The chi-square test showed that the IPSS-R score and CD7 expression were strong prognostic factors. Patients whose MDS blasts expressed high levels of CD7 (17% or more MDS blasts were CD7+) had significantly shorter survival than other patients.Conclusion: This study confirmed the prognostic impact of both the IPSS-R score and CD7 expression on MDS blasts in Japanese MDS patients.

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