演題詳細

ポスター / Poster

ポスター 13 (Poster 13) :MDS:臨床 2

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日程
2013年10月11日(金)
時間
16:50 - 17:50
会場
ポスター会場 / Poster (ロイトン札幌 3F ロイトンホールABCD)
座長・司会
太田 健 (Ken Ota):1
1:弘前大学大学院医学研究科 消化器血液内科学講座
 
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Clinical characteristics of myelodysplastic syndromes in Nagasaki atomic bomb survivors

演題番号 : PS-1-93

松尾 真稔 (Masatoshi Matsuo):1、岩永 正子 (Masako Iwanaga):2,3、今西 大介 (Daisuke Imanishi):1,3、今泉 芳孝 (Yoshitaka Imaizumi):1,3、田口 潤 (Jun Taguchi):1,3、澤山 靖 (Yasushi Sawayama):1,3、対馬 秀樹 (Hideki Tsushima):1,3、波多 智子 (Tomoko Hata):1,3、宮崎 泰司 (Yasushi Miyazaki):1,3

1:Dept. Hematol., Nagasaki Univ. Hospital, Nagasaki, Japan、2:Teikyo School of Public Health, Tokyo, Japan、3:Dept. Hematol., Nagasaki Univ. A-Bomb Disease Inst., Japan

 

We previously reported a clear relationship between an increasing incidence of Myelodysplastic syndromes (MDS) and a higher radiation exposure in Nagasaki atomic bomb survivors (Iwanaga et al, JCO 2011). Whether radiation exposure affects the clinical characteristics and the prognosis of MDS is our next concern. We evaluated 111 patients with de novo MDS (median age 70.6 years, male 50%) identified in Nagasaki atomic bomb survivors during 1985-2011 and evaluable for IPSS score and exposure distance. The frequency of IPSS risk-based cytogenetic group was significantly different by exposure distance (i.e. the poor type was significantly high in those exposed within 1.5km, P<0.0001), but the frequencies of IPSS cytopenia score and the total IPSS score did not differ by exposure distance. By the end of 2012, 40 (36.0%) patients transformed to leukemia and 88 (79.3%) have died. The 10-yr overall survival tended to be poorer in those exposed within 1.5km, but it was not statistically significant. The cumulative Incidence rate of leukemic transformation also tended to be higher in those exposed proximally, but the difference was not statistically significant. These data suggest that radiation exposure could be related with a poor prognosis beyond the effect of IPSS on MDS among atomic bomb survivors, but we have so far not observed the clear impact of radiation exposure on the prognosis of MDS. Additional efforts are underway to accumulate more information from more large number of subjects.

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