演題詳細

ポスター / Poster

ポスター 12 (Poster 12) :MDS:臨床 1

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日程
2013年10月11日(金)
時間
16:50 - 17:50
会場
ポスター会場 / Poster (ロイトン札幌 3F ロイトンホールABCD)
座長・司会
波多 智子 (Tomoko Hata):1
1:長崎大学原爆後障害医療研究所 血液内科学研究分野(原研内科)
 
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Clonal evolution with i(17q) in a leukemic transformed patient from MDS after treatment with aza

演題番号 : PS-1-83

三好 隆史 (Takashi Miyoshi):1、井尾 克宏 (Katsuhiro Io):1、鷹尾 珠美子 (Sumiko Takao):1、永井 謙一 (Kenichi Nagai):1

1:Kansai electric power hospital, Osaka, Japan

 

Isochromosome 17q has been reported in rare cases of myelodysplastic syndrome(MDS),with an incidence of approximately 1%. Here,we describe a new case of MDS with PRCA, which also progressed acute myeloid leukemia and basophilia after treatment with 5-azacitidine with chromosomal additional abnormality, i(17q).64year-old man presented with bicytopenia: hemoglobin 42g/L, reticulocytes5.54×109/L,platelets 232×109/L,and leukocytes 2.2×109/L without blasts.Bone marrow was hypocellular with1.9% erythroblasts. Dysplastic change including micromegakaryocytes was found. The result of bone marrow aspiration was compatible with MDS associated with erythroid hypoplasia and eosinophilia. Cytogenetic analysis of bone marrow showed 46,XY,add(12)(p11.2)[3]. Because the patient was transfusion dependent, 5-azacitidine therapy was started. Anemia was transiently improved, but immediately return to transfusion dependent. The patient evolved to acute myeloid leukemia and basophilia with additional i(17q) abnormality six months after stopping treatment. 5-azacitidine was restarted and the patient has been received outpatient chemotherapy. MDS associated with erythroid hypoplasia are rare forms of MDS and it was reported that i(17q) may be implicated in the pathogenesis of MDS with PRCA. But in this case, karyotypic abnormality involved in the onset of MDS with PRCA was add(12)(p11.2). Our analysis suggests i(17q) may be associated with leukemic transformation with basophilia in the MDS patient.

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