演題詳細

一般口演 / Oral Session

一般口演 8 (Oral Session 8) :MDS:臨床 2

print

日程
2013年10月11日(金)
時間
10:30 - 11:30
会場
第6会場 / Room No.6 (ロイトン札幌 2F エンプレス)
座長・司会
前田 嘉信 (Yoshinobu Maeda):1
1:岡山大学病院 血液・腫瘍・呼吸器・アレルギー内科
 
前へ戻る

Influence of concomitant use of azacitidine and deferasirox on the renal function

演題番号 : OS-1-39

米田 美栄 (Mie Yoneda):1、岡部 崇志 (Takashi Okabe):1、朝倉 崇徳 (Takanori Asakura):1、細田 亮 (Toru Hosoda):1、横山 明弘 (Akihiro Yokoyama):1、朴 載源 (Saigen Boku):1、矢野 尊啓 (Takahiro Yano):1、上野 博則 (Hironori Ueno):1

1:Dept. of Hematology, National Tokyo Medical Center, Japan

 

[Introduction] Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only treatment for myelodysplastic syndrome (MDS) with curative potential, but most patients with MDS are not good candidates for allo-HSCT due to their old age. Azacitidine has shown a survival advantage compared with best alternative care in patients with high-risk MDS. Several recent studies have demonstrated a survival benefit of iron chelation therapy in heavily transfused patients with MDS. Deferasirox is a once-daily oral iron chelator. Concomitant use of azacitidine and deferasirox for MDS may increase. Both drugs have renal toxicity, but little is known about the infuence on the renal function. We reviewed retrospectively the serum creatinine levels of ten patients who were administered azacitidine and deferasirox at the same time in our hospital. [Results] Nine of ten patients were males and one female. According to WHO classification, there were three patients classified as RAEB-1, two as RAEB-2, two as AML-MRC, one as RCMD, one as RARS, one as RA. Dose of desferasirox was 10-30 mg/kg/day (median 18 mg/kg/day). Seven patients received only one course of azacitidine therapy , and three patients received 3, 5, 6 courses. In six patients, serum creatinine values increased (5 grade1, 1 grade2) , but all elevations were temporary. Creatinine levels after the combination therapy did not deteriorate more than the single use of azacitidine or deferasirox in each patient. [Conclusion] Azacitidine and deferasirox can be used safely at the same time.

前へ戻る