演題詳細

一般口演 / Oral Session

一般口演 8 (Oral Session 8) :MDS:臨床 2

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日程
2013年10月11日(金)
時間
10:30 - 11:30
会場
第6会場 / Room No.6 (ロイトン札幌 2F エンプレス)
座長・司会
前田 嘉信 (Yoshinobu Maeda):1
1:岡山大学病院 血液・腫瘍・呼吸器・アレルギー内科
 
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Efficacy of azacitidine in cases of poor risk MDS in Sanin Area

演題番号 : OS-1-37

景山 康生 (Kousei Kageyama):1、小村 裕美 (Hiromi Omura):1、田中 順子 (Junko Tanaka):1、田中 孝幸 (Takayuki Tanaka):1、鈴宮 淳司 (Junji Suzumiya):1、吾郷 浩厚 (Hiroatsu Ago):1

1:Sanin Hematology Meeting,Izumo,Japan

 

[Background] Azacitidine(AZA) is a anti-MDS agent and it was approved at 2011 in Japan. The agent is now being the key drug to treat and management of MDS. Then we examined its effect and long term clinical outcome at Sanin area. [Patients and methods] We retrospectively analyzed 25Pts of MDS treated by AZA from Aug 2011 to Jan 2013. Median age was 77(55 -85). There were fifteen RAEB1 or 2 cases and AML/MRC were 3cases. In 9cases, karyotype risk was poor. Risk group was low(n=3), int(n=2), high(n=10), very high(n=7) with WPSS. 2Pts were considered secondary MDS, from long term chemotherapy for MPD, lung cancer, respectively. 6Pts were prepared for alloSCT. [Result] Median observation time was 14 months, and 5Pts were continuing AZA (4-13cycles). There were 3cases of progression to overt leukemia. The efficacies were evaluated by response criteria of The Cancer and Leukemia Group B, PR; 3, and Improved; 7. Improvement of blood cell counts were achieved in trilineage;3, bi ;1, mono;4, respectively. 5Pts achieved transfusion free. Adverse events except hematological toxicity were infection 9, constipation 3, nasal bleeding 1. 1Year overall survival (OS) and leukemia free survival (LFS) were 50.9% and 33.9% respectively [Discussion]AZA was well tolerable for elderly patient, and showed moderate effect. However, OS and LFS in our study were not so good as foreign clinical studies. The reason of this gap might be longer interval of AZA cycle and many dropped out cases in our study. This result suggested that, to repeat enough cycles in constant interval with courage is important.

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