演題詳細

一般口演 / Oral Session

一般口演 7 (Oral Session 7) :MDS:臨床 1

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日程
2013年10月11日(金)
時間
09:30 - 10:30
会場
第6会場 / Room No.6 (ロイトン札幌 2F エンプレス)
座長・司会
南谷 泰仁 (Yasuhito Nannya):1
1:東京大学 血液・腫瘍内科
 
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Association between CD34 and p53 expression in bone marrow and clinical features in MDS patients

演題番号 : OS-1-33

半下石 明 (Akira Hangaishi):1、木原 淳 (Atsushi Kihara):2、安藤 弥生 (Yayoi Ando):1、齋賀 真言 (Makoto Saika):1、遅塚 明貴 (Aki Chizuka):1、木田 理子 (Michiko Kida):1、村田 建一郎 (Kenichiro Murata):2、臼杵 憲祐 (Kensuke Usuki):1

1:Department of Hematology, NTT Medical Center Tokyo, Japan、2:Department of Diagnostic Pathology, NTT Medical Center Tokyo, Japan

 

Myelodysplastic syndrome (MDS) is a hematological disorder characterized by ineffective hematopoiesis and a tendency to develop acute leukemia. Several predictive indicators for prognosis including IPSS have been applied because of its heterogenity. Increased CD34 expression in bone marrow (BM) also reported to be associated with high risk MDS. In this study, we analyzed the association between immunohistological status of CD34 and other stem cell related proteins in BM and clinical features in MDS patients. Totally 63 BM specimens were available to analyze the immunoreactivity with CD34, p53, TdT or c-kit antibodies. The positive cells in particles were counted and patients were categorized into three groups (low, intermediate and high) according to the percentage of positive cells. The relationship of each protein's expression pattern and prognostic factors were analyzed. CD34 positive cells in high risk group (INT2 and high) were detected more frequently than those in low risk (low and INT1). Although the numbers of p53 positive cells were not associated with IPSS and WPSS, leukemic transformations were occurred more frequently in high p53 group (six of thirteen) than in low p53 group (one of seventeen). In this study, CD34 and p53 expression were related to poor prognosis or leukemic transformation. The increased number of CD34 positive cells might associate with maturation arrest or increase of leukemic cells. The increase of p53 positive cells might associate with p53 mutant neoplastic cells proliferation because p53 overexpression often relates to p53 gene mutation.

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